Novel Targets Podcast

Bringing to Life the Science around Innovative New Drugs, Gene and Cell Therapies

In this latest episode, we tackle the family of protein molecules called cytokines that can have a yin and yang effect on the tumour microenvironment in many solid tumours.

Computer Graphic of TGFβ   Credit: Dr Michael Sporn, NCI

What are they and can we manipulate them and modulate their signal so as to tip things in a more positive direction in people with cancer?

Examples of cytokines include the interleukin (IL) family, interferon gamma (IFN𝛄), and transforming growth factor beta (TGFβ).

Welcome back to Season 4! This episode of Novel Targets was recorded at the 2018 annual meeting of the American Association for Cancer Research (AACR) in Chicago. This time around, we’re talking about cancer immunotherapy clinical practice, pitfalls in trial design/interpretation, emerging biomarkers, and possibilities for future cures in some patients.

Professor Tom Powles

Tom Powles (Barts Cancer Centre) is a regular on the podcast. He previously featured in Episode 7 , where he talked about some of his experience with the checkpoint inhibitor, atezolizumab, in bladder cancer.

In the final episode of Season 3 we journey to Atlanta, Georgia for the 2017 American Society of Hematology (ASH) annual meeting to learn more about the latest developments in hematologic malignancies, including leukemias, lymphomas and multiple myeloma.

Contrary to popular perception, it isn’t always warm and sunny in the southern states – Brrrr!:

For this episode, we interviewed an eclectic line-up of experts, some of whom abandoned the rose tinted glasses to take a more honest and realistic approach to oncology R&D:

In our latest episode, we’re tackling the thorny issue of therapeutic cancer vaccines.  Nothwithstanding some recent clinical trial failures, there’s still considerable interest in this topic.

Are we on the threshold of a renaissance — a rebirth or awakening in the way we can stimulate the immune system to attract more cytolytic T cells into the tumour?  If not, what needs to be done for this to happen?  If so, what would the new approach(es) look like and how would they differ from what’s gone before?

In this episode we cover several important and related topics, including: the importance of pre-existing Immunity and novel ways to activate the immune system through Cancer Vaccines, Cytokines, Immune Agonists & T cell bispecifics.

The majority of these interviews were recorded at the American Society of Clinical Oncology (ASCO) meeting held in Chicago in June 2017, while others were recorded in Paris or at the Society for Immunotherapy of Cancer (SITC) meeting in National Harbor, MD.

Pre-Existing Immunity

Dr Jérôme Galon

Dr Jérôme Galon

Dr Jérôme Galon (INSERM) is a leading immunologist who works for the French NIH and is co-founder of a diagnostic company, HalioDx.