In this latest episode, we tackle the family of protein molecules called cytokines that can have a yin and yang effect on the tumour microenvironment in many solid tumours.

Computer Graphic of TGFβ   Credit: Dr Michael Sporn, NCI

What are they and can we manipulate them and modulate their signal so as to tip things in a more positive direction in people with cancer?

Examples of cytokines include the interleukin (IL) family, interferon gamma (IFN𝛄), and transforming growth factor beta (TGFβ).

Welcome back to Season 4! This episode of Novel Targets was recorded at the 2018 annual meeting of the American Association for Cancer Research (AACR) in Chicago. This time around, we’re talking about cancer immunotherapy clinical practice, pitfalls in trial design/interpretation, emerging biomarkers, and possibilities for future cures in some patients.

Professor Tom Powles

Tom Powles (Barts Cancer Centre) is a regular on the podcast. He previously featured in Episode 7 , where he talked about some of his experience with the checkpoint inhibitor, atezolizumab, in bladder cancer.