This episode features interviews with two Titans in the field of adoptive cell therapy: Dr Carl June from the University of Pennsylvania (UPenn) and Dr Steven Rosenberg from the National Cancer Institute (NCI).

Adoptive cellular therapy is where you take T lymphocytes – T cells, “the immune warriors in the body” as you’ll Dr Rosenberg describe them, out of a patient, manipulate them in some way in the laboratory, then expand them in terms of numbers and give them back to the patient.

Dr Carl June UPenn

Dr Carl June talks about one way of manipulating a T lymphocyte through the insertion of a Chimeric Antigen Receptor (CAR) to create a CAR modified T cell.