Welcome back to Season 3!

In this episode we’re tackling one of the hottest topics in cancer research, why do cancer immunotherapies work in some people, but not in others? Why do they stop working? If we want to obtain long durable responses, then we have to understand and overcome resistance. Some of the meaty topics covered on this episode include:

  • Initial resistance
  • Acquired resistance
  • Immune escape
  • How we may be able to turn non-responders into responders
  • Overcoming immuno-suppression within the tumor microenvironment.

This episode features excerpts from an interview with Dr Holbrook Kohrt who was leading the way in researching the potential of immune agonists targeting 4-1BB (CD137). It is with great sadness that we must report that since this episode aired, Holbrook Kohrt is no longer with us. He died, aged 38, on February 24, 2016.

Dr Holbrook Kohrt Stanford

In-Memorium Holbrook Kohrt